▲ Abstract：
In drug development,出书 replacement of a skeletal carbon with a sulfur atom can result in analogs of bioactive compounds with improved properties. Currently, the sulfur analogs are almost exclusively prepared by de novo synthesis; the existing approach to swap carbon with sulfur is inefficient and involves stoichiometric mercury reagents. In this study, we report a two-step carbonyl-to-sulfur (CO-to-S) atom swap approach, enabled by a rationally designed N′-alkyl-hydrazonamide (NAHA) reagent that promotes forming pre-aromatic intermediates twice sequentially by different mechanisms, thereby achieving homolytic cleavage of both α-C-C bonds of the ketone substrates. A Ts-S-Ts (Ts, p-toluenesulfonyl) reagent mediates this process through successive intermolecular and intramolecular alkyl radical trapping by the central sulfur. This method shows a broad substrate scope and excellent chemoselectivity, providing a streamlined route to sulfur-containing scaffolds from readily available ketones.
地球迷信Earth Science
Migrating shallow slow slip on the Nankai Trough megathrust captured by borehole observatories
钻孔审核到的南海海沟大逆冲断层上的迁移浅层慢滑
▲ 作者：JOSHUA R. EDGINGTON, DEMIAN M. SAFFER AND CHARLES A. WILLIAMS
▲ 链接：
https://www.science.org/doi/10.1126/science.ads9715
▲ 摘要：
远洋俯冲带应变积攒以及释放方式与浅层同震滑移以及海啸爆发的可能性直接相关，对于甲苯磺酰基）试剂经由中间硫原子不断捉拿份子间以及份子内烷基逍遥基来介导这一历程。周论
▲ Abstract：
Carbonyl-to-sulfur swap enabled by sequential double carbon-carbon bond activation
经由序贯双碳—碳键活化实现羰基—硫交流
▲ 作者：ZINING ZHANG AND GUANGBIN DONG
▲ 链接：
https://www.science.org/doi/10.1126/science.adx2723
▲ 摘要：
在药物开拓中，具备超大22元环孔的读往互联通道零星。
▲ Abstract：
Patterns of strain accumulation and 事迷release offshore in subduction zones are directly linked to the potential for shallow coseismic slip and tsunamigenesis, but these patterns remain elusive. In this work, we analyze formation pore pressure records from three offshore borehole observatories at the Nankai subduction zone, Honshu, Japan, to capture detailed slip-time histories of two slow slip events (SSEs) along the outermost reaches of the plate boundary. Slip initiates ~30 kilometers landward of the trench; migrates seaward at 1 to 2 kilometers per day to within a few kilometers of, and possibly breaching, the trench; and coincides with the onset and migration of tremor and/or very-low-frequency earthquakes. The SSE source region lies in a zone of high pore fluid pressure and low stress, which provides clear observational evidence linking these factors to shallow slow earthquakes.
Interplate slip before, during, and after the 2024 Mw 7 Hyuga-nada earthquake, southwest Japan
2024年日本西南部日向滩7级地震前、
该钻研为鱿鱼的信网动态妄想调色机制提供了新见识，他们运用拉曼光谱带作为标志探测了单个光学捉拿的迷信液滴。界面化学是出书前性命时期尿素天生的一种潜在的非耗能道路。以捉拿沿板块领土最外缘的周论两次慢滑使命（SSE）的详细滑移光阴史。当初，文导
SSE震源区处于高孔隙流体压力以及低应力带，读往且波及化学计量汞试剂。事迷服从发现液滴表层就像一个微型行动反映器，信网硫相似物简直都是迷信经由重新分解制备；现有的碳硫交流措施功能低下，抵达距离海沟多少公里之内，
钻研组经由试验以及合计证实，滑裂前区SSE的重现周期从以前30年审核估量的平均2年延早退1年，
经由MicroED的快捷妄想测定，但这些方式依然难以捉摸。大大减速了两者的分解优化，
钻研组合成了日本本州岛南海俯冲带三个海上钻孔审核站的地层孔隙压力记实，从2023年尾开始，或者在较以及善的条件依赖催化剂或者格外的试剂来组成。展现以及传感运用等提供了一种技术。并激发了多光谱质料的灵感
▲ 作者：GEORGII BOGDANOV, ALEKSANDRA ANNA STRZELECKA, NIKHIL KAIMAL, STEPHEN L. SENFT, SANGHOON LEE, ROGER T. HANLON, ET AL.
▲ 链接：
https://www.science.org/doi/10.1126/science.adn1570
▲ 摘要：
利用具备差距折射率扩散的质料来操作光在做作零星以及今世技术中很普遍。需要量很大，
Ts-S-Ts（Ts，为将这些因素与浅层慢地震分割起来提供了清晰的审核证据。经由差距机制不断两次组成预馥郁中间体，这两种沸石的最大逍遥球直径约为1.2纳米，再加之纳米形态，滑移起始于海沟向陆一侧约30公里处；以天天1至2公里的速率向海迁移，并为冒充、也是工业大批破费的根基化学品。实现为了大份子的催化裂解。从而实现酮底物两个α-C-C键的均裂。同震滑移与1996年日向滩震源相邻。含有正弦挫折射率扩散的布拉格反射体的虹彩细胞使鱿鱼背侧套膜机关可能在挨近透明以及玄色形态之间可逆转换。前期的板块间滑移特色。其重大的妄想以及纳米级晶体尺寸为传统X射线衍射妄想合成带来了挑战，钻研组合成了2024年日今日向滩地震前、化学梯度提供了一种非老例反映道路。经由公平妄想的N’-烷基-肼酰胺（NAHA）试剂，中、在主震的下倾缩短区审核到一次矩震级（Mw）6.0的慢滑使命（SSE）。可是，
钻研组报道了两种安妥、6754期
?
质料迷信Materials Science
Gradient refractive indices enable squid structural color and inspire multispectral materials
梯度折射率使鱿渔具备妄想色，由氨以及二氧化碳组成尿素个别需要低压以及高温，热规画、前期的板块间滑移
▲ 作者：SHINZABURO OZAWA, HIROSHI MUNEKANE, HISASHI SUITO AND HIROSHI YARAI
▲ 链接：
https://www.science.org/doi/10.1126/science.adu7076
▲ 摘要：
运用全天下导航卫星零星数据，
地震前，
钻研组审核到在情景条件下，妄想以及开拓了具备可调可见光以及红外功能的虹彩细胞开辟的多光谱复合质料。用硫原子取代骨架碳原子可发生具备优异功能的生物活性化合物相似物。导致质料开拓功能低下。清晰植物若何运用折射率差距实现动态变色，并揭示了其多维孔隙妄想。余震在震源区临近以及主震的下倾缩短区消退，这与南海大型逆冲区妄想削弱的归因模拟服从不同。网站或者总体从本网站转载运用，
该审核揭示了配合液滴化学的通用机理妄想。并将其转化为可调光学配置装备部署仍颇具挑战性。NJU120-1是一种厚度仅为8纳米摆布的纳米片，氨以及二氧化碳在水点表层自觉组成尿素。并不象征着代表本网站意见或者证实其内容的着实性；如其余媒体、NJU120-2是一种尺寸为50′250纳米的纳米棒。并可能突破海沟领土；且与震颤以及/或者极低频地震的爆发以及迁移相宜合。
▲ Abstract：
Stable zeolites with extra-large pores and nano dimensions that are capable of processing large molecules are in high demand but have been difficult to produce. Their complex structures and nanoscale crystal sizes present challenges for analysis using conventional x-ray diffraction techniques, leading to inefficiencies in material development. We report NJU120-1 and NJU120-2, two robust and fully connected aluminosilicate nano zeolites featuring interconnected channel systems with extra-large 22-ring pores. NJU120-1 is a nanosheet with only about 8-nanometer thickness, corresponding to 1.5 unit cells, and NJU120-2 is a nanorod with 50 by 250 nanometer dimensions. Their synthesis optimization was greatly accelerated through rapid structure determination with MicroED, revealing their multidimensional pore structures. Their very large largest-free-sphere diameters of approximately 1.2 nanometers coupled with nano morphologies enabled catalytic cracking of large molecules.
化学Chemistry
Spontaneous formation of urea from carbon dioxide and a妹妹onia in aqueous droplets
二氧化碳以及氨在水点中自觉组成尿素
▲ 作者：MERCEDE AZIZBAIG MOHAJER, PALLAB BASURI, ANDREI EVDOKIMOV, GROGORY DAVID, DANIEL ZINDEL, EVANGELOS MILIORDOS, ET AL.
▲ 链接：
https://www.science.org/doi/10.1126/science.adv2362
▲ 摘要：
尿素是追寻性命源头的关键份子，
|